Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HRH1 | P35367 | 10/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15568616 | 0.82 | LMNA (0.49) | CYP2D6LMNATP53MAPTNPSR1 | |
| SCHEMBL15569125 | 0.80 | PKM (0.60) | PKMSMN1; SMN2HRH1CYP2D6KCNH2 | |
| SCHEMBL15568082 | 0.80 | HRH1 (0.47) | HRH1CYP2D6KCNH2LMNATP53 | |
| SCHEMBL15568646 | 0.75 | PKM (0.60) | PKMSMN1; SMN2HRH1CYP2D6KCNH2 | |
| SCHEMBL15568900 | 0.73 | GAA (0.53) | PKMHRH1CYP2D6KCNH2HTR3A | |
| SCHEMBL15569119 | 0.73 | PKM (0.59) | PKMSMN1; SMN2HRH1CYP2D6KCNH2 | |
| SCHEMBL15567339 | 0.72 | PKM (0.60) | PKMSMN1; SMN2HRH1CYP2D6KCNH2 | |
| SCHEMBL15569126 | 0.71 | HRH1 (0.66) | PKMHRH1CYP2D6KCNH2HTR3A | |
| SCHEMBL15567208 | 0.70 | HRH1 (0.56) | HRH1CYP2D6KCNH2HTR3ACHRM1 | |
| SCHEMBL15568787 | 0.69 | HRH1 (0.62) | PKMHRH1CYP2D6KCNH2HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | claimed |
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |