Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A2 | O94788 | 4/20 | 0.46 |
| ▸ | ALDH2 | P05091 | 4/20 | 0.46 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.46 |
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15567867 | 0.82 | ALDH1A1 (0.67) | LMNAMAPTALDH1A1MEN1CYP1A2 | |
| SCHEMBL15569560 | 0.82 | PKM (0.56) | LMNATP53MAPTCYP2D6NPSR1 | |
| SCHEMBL15569311 | 0.78 | ALDH1A1 (0.61) | LMNAMAPTALDH1A1MEN1CYP1A2 | |
| SCHEMBL7069980 | 0.76 | TSHR (0.54) | LMNAMAPTALDH1A1CYP2D6 | |
| SCHEMBL7074071 | 0.73 | KDM4E (0.56) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL15569020 | 0.72 | MEN1 (0.67) | LMNAMAPTALDH1A1MEN1CYP1A2 | |
| SCHEMBL15568760 | 0.72 | ALDH1A1 (0.55) | LMNAMAPTALDH1A1MEN1CYP1A2 | |
| SCHEMBL15569410 | 0.71 | ALDH1A1 (0.56) | LMNAMAPTALDH1A1MEN1CYP1A2 | |
| SCHEMBL7076863 | 0.69 | LSS (0.49) | LMNATP53MAPTALDH1A1POLB | |
| SCHEMBL15568082 | 0.69 | HRH1 (0.47) | LMNATP53MAPTCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | claimed |
| WO-2014027053-A1 | BENZIMIDAZOLES FOR THE TREATMENT OF CANCER | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-02-20 | — | — | WO | disclosed |