Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13211888 | 0.87 | SMN1; SMN2 (0.58) | SMN1; SMN2LMNAHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL19303132 | 0.86 | SMN1; SMN2 (0.56) | SMN1; SMN2LMNAHPGDL3MBTL1MAPK1 | |
| SCHEMBL10264109 | 0.86 | SMN1; SMN2 (0.60) | SMN1; SMN2LMNAHPGDL3MBTL1MAPK1 | |
| SCHEMBL14640097 | 0.85 | WDR5 (0.54) | SMN1; SMN2LMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL10203253 | 0.85 | LMNA (0.59) | SMN1; SMN2LMNAL3MBTL1ALDH1A1MAPT | |
| SCHEMBL25442207 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAHPGDL3MBTL1ALDH1A1 | |
| SCHEMBL22042473 | 0.83 | EPHX2 (0.56) | SMN1; SMN2LMNAHPGDL3MBTL1MAPK1 | |
| SCHEMBL10203247 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAHPGDL3MBTL1MAPK1 | |
| SCHEMBL13734696 | 0.81 | ALDH1A1 (0.58) | SMN1; SMN2LMNAHPGDL3MBTL1MAPK1 | |
| SCHEMBL17824998 | 0.81 | ALDH1A1 (0.59) | SMN1; SMN2LMNAHPGDL3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605596-A | Compositions and methods for inducible alternative splicing modulation of gene expression | 费城儿童医院（US） | 2023-01-13 | — | — | CN | disclosed |
| EP-3852752-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2021-07-28 | — | — | EP | disclosed |
| WO-2020061377-A1 | SPIROCYCLIC 2,3-DIHYDRO-7-AZAINDOLE COMPOUNDS AND USES THEREOF | GENENTECH, INC. (US) | 2020-03-26 | — | — | WO | disclosed |
| EP-2885288-A1 | 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS | Novartis AG (CH) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014028459-A1 | 1,4-DISUBSTITUTED PYRIDAZINE ANALOGS AND METHODS FOR TREATING SMN-DEFICIENCY-RELATED CONDITIONS | NOVARTIS AG (CH) | 2014-02-20 | — | — | WO | disclosed |