Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.45 |
| ▸ | DRD3 | P35462 | 4/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.44 |
| ▸ | KDM1A | O60341 | 2/20 | 0.43 |
| ▸ | PNMT | P11086 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.39 |
| ▸ | CHRNG | P07510 | 1/20 | 0.39 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24593614 | 1.00 | DRD2 (0.45) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL16906757 | 0.89 | DRD2 (0.50) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL24593570 | 0.89 | DRD2 (0.50) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL14072565 | 0.88 | LRRK2 (0.46) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL2818458 | 0.81 | PGR (0.48) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL6141623 | 0.81 | CYP11B1 (0.49) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL10192249 | 0.81 | LRRK2 (0.44) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL12058460 | 0.77 | LRRK2 (0.43) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL14450170 | 0.77 | LRRK2 (0.43) | DRD2DRD3LRRK2KDM1APNMT | |
| SCHEMBL15491209 | 0.77 | LRRK2 (0.43) | DRD2DRD3LRRK2KDM1APNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020127685-A1 | AMINO-ACID ANILIDES AS SMALL MOLECULE MODULATORS OF IL-17 | LEO PHARMA A/S (DK) | 2020-06-25 | — | — | WO | disclosed |
| US-8674095-B2 | Compounds for treating neuropsychiatric conditions | AFRAXIS HOLDINGS, INC. (US) | 2014-03-18 | — | — | US | disclosed |
| CN-1849121-A | Piperazine derivatives as bradyknin antagonist | AMGEN INC (US) | 2006-10-18 | — | — | CN | disclosed |