Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13183732 | 0.89 | CYP11B2 (0.58) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL10238652 | 0.79 | MEN1 (0.61) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL14565127 | 0.77 | ALDH1A1 (0.57) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL14565128 | 0.76 | PKM (0.52) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL14565111 | 0.75 | CYP11B2 (0.50) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL782484 | 0.73 | CYP11B2 (0.85) | CYP11B2GPR55 | |
| SCHEMBL5539787 | 0.72 | MEN1 (0.59) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL14565110 | 0.71 | CYP11B2 (0.52) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL9463910 | 0.71 | MAPK1 (0.52) | CYP11B2ALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL9463794 | 0.70 | MAPK1 (0.54) | CYP11B2ALDH1A1HPGDKDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-B1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-03-19 | — | — | EP | disclosed |