Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 2/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.30 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164250 | 0.92 | MALT1 (0.35) | MALT1SYKGPR55P2RX3KDM4E | |
| SCHEMBL474539 | 0.92 | MALT1 (0.35) | MALT1SYKGPR55P2RX3KDM4E | |
| SCHEMBL2817510 | 0.86 | MAPT (0.41) | MALT1SYKGPR55KDM4ENPC1 | |
| SCHEMBL15580679 | 0.85 | ALDH1A1 (0.32) | ALDH1A1 | |
| SCHEMBL474532 | 0.85 | GPR55 (0.33) | MALT1SYKGPR55P2RX3ALDH1A1 | |
| SCHEMBL12164254 | 0.85 | GPR55 (0.33) | MALT1SYKGPR55P2RX3ALDH1A1 | |
| SCHEMBL474353 | 0.83 | LMNA (0.41) | MALT1GPR55P2RX3SCN9ASCN10A | |
| SCHEMBL12164239 | 0.83 | LMNA (0.41) | MALT1GPR55P2RX3SCN9ASCN10A | |
| SCHEMBL474506 | 0.83 | ALDH1A1 (0.32) | MALT1GPR55KDM4EALDH1A1MAPK1 | |
| SCHEMBL2816930 | 0.83 | ALDH1A1 (0.32) | MALT1GPR55KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411365-B1 | 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2014-03-19 | — | — | EP | disclosed |