Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRB1ADRB2ADRB3CYP11B1DPP4FGFR1FGFR2FGFR3FGFR4HRH1JAK1JAK2JAK3KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITNAOPRD1OPRK1OPRM1PPDGFRBPIK3CDSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASMOTYK2polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | PPARD | Q03181 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | LAP3 | P28838 | 1/20 | 0.35 |
| ▸ | FDPS | P14324 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 3/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.35 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL514882 | 1.00 | TSHR (0.42) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL8633019 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL4830427 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL9451023 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL1091790 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL23069487 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL7994686 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL1781807 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL1092628 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 | |
| Ether SCHEMBL28296617 | 0.97 | TSHR (0.40) | TSHRPPARDALDH1A1TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8576 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118325677-A | Antistatic detergent and application thereof | 厦门当盛新材料有限公司 | 2024-07-12 | — | — | CN | claimed |
| CN-118165606-B | Preparation method of polylactic acid type full-degradable water-based gloss oil | 上海高邦印刷材料有限公司 | 2024-07-05 | — | — | CN | claimed |
| EP-4392003-A1 | PERSONAL CARE COMPOSITIONS | Colgate-Palmolive Company (US) | 2024-07-03 | — | — | EP | claimed |
| CN-114695834-B | Alkaline cell with improved discharge efficiency | 劲量品牌有限责任公司 | 2024-06-25 | — | — | CN | claimed |
| CN-118165606-A | Preparation method of polylactic acid type full-degradable water-based gloss oil | 上海高邦印刷材料有限公司 | 2024-06-11 | — | — | CN | claimed |
| US-11998628-B2 | Personal care compositions | COLGATE-PALMOLIVE COMPANY (US) | 2024-06-04 | — | — | US | claimed |
| WO-2024112564-A1 | ULTRA-LIGHTWEIGHT PROPPANTS | SAUDI ARABIAN OIL COMPANY (SA) | 2024-05-30 | — | — | WO | claimed |
| CN-118085948-A | Environment-friendly water-based steel cord wet-drawing lubricant | 上海华谊控股集团有限公司 | 2024-05-28 | — | — | CN | claimed |
| US-20240166941-A1 | ULTRA-LIGHTWEIGHT PROPPANTS | SAUDI ARABIAN OIL COMPANY (SA) | 2024-05-23 | — | — | US | claimed |
| CN-118055985-A | Composition containing metal oxide particles with reduced production of volatile aldehydes | 日产化学株式会社 | 2024-05-17 | — | — | CN | claimed |
| US-4477617-A | Molding resins based on blends of acid copolymer/hydrocarbon polyolefin/reinforcing fiber/wetting agent | E. I. DUPONT DE NEMOURS AND COMPANY (US) | 1984-10-16 | — | — | US | claimed |
| EP-0049740-B1 | PROCESS FOR THE CONTINUOUS PREPARATION OF DIALKYLPEROXYDICARBONATES | Peroxid-Chemie GmbH (DE) | 1984-02-22 | — | — | EP | claimed |
| EP-0100066-A1 | Surfactant-containing filled and plasticized thermoplastic compositions based on ethylene interpolymers | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-02-08 | — | — | EP | claimed |
| US-4430468-A | SOUND DEADENING COATINGS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-02-07 | — | — | US | claimed |
| EP-0099581-A2 | Molding resins based on blends of acid copolymer/hydrocarbon polyolefin/reinforcing fiber/wetting agent | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1984-02-01 | — | — | EP | claimed |
| EP-0085501-A2 | Improvements in pesticidal formulations | THE DOW CHEMICAL COMPANY (US) | 1983-08-10 | — | — | EP | claimed |
| EP-0084457-A1 | Derivatives of biologically active substituted tin compounds, emulsifiable concentrates of said derivatives and methods of controlling plant infestations | THE DOW CHEMICAL COMPANY (US) | 1983-07-27 | — | — | EP | claimed |
| US-4384965-A | Method for the mechanical working of metals and lubricant concentrate | BEROL KEMI AB (SE) | 1983-05-24 | — | — | US | claimed |
| EP-0034132-A2 | Method for the mechanical working of metals and lubricant concentrate | BEROL KEMI AB (SE) | 1981-08-19 | — | — | EP | claimed |
| US-4131581-A | Adhesive compositions consisting essentially of a vinyl alcohol polymer, a crystalline solvent and a viscosity reducing diluent | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1978-12-26 | — | — | US | claimed |