Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20403817 | 0.76 | CCR1 (0.34) | TDP1L3MBTL1 | |
| SCHEMBL8272903 | 0.75 | ALDH1A1 (0.44) | TDP1L3MBTL1PARP1ALDH1A1NPSR1 | |
| SCHEMBL4175060 | 0.74 | S1PR4 (0.34) | CPB2ALDH1A1NPSR1 | |
| SCHEMBL19788237 | 0.74 | CHRNB2 (0.40) | TDP1L3MBTL1PARP1ALDH1A1NPSR1 | |
| SCHEMBL336025 | 0.73 | RECQL (0.37) | CPB2 | |
| SCHEMBL15220986 | 0.73 | LOX (0.33) | TDP1L3MBTL1CPB2 | |
| SCHEMBL18266782 | 0.73 | CSNK2A1 (0.41) | CPB2 | |
| SCHEMBL17002597 | 0.73 | CPB2 (0.33) | CPB2 | |
| SCHEMBL10780675 | 0.72 | CPB2 (0.47) | CPB2PARP1 | |
| SCHEMBL21120992 | 0.72 | MRGPRX4 (0.33) | RXRAGRIN1GRIN2BTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014153037-A1 | SUBSTITUTED TRIAZOLOPYRIDINES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-25 | — | — | WO | disclosed |
| WO-2014144545-A2 | SUBSTITUTED BENZOXAZOLES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| WO-2014008458-A2 | N-SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2014-01-09 | — | — | WO | disclosed |