Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152483 | 0.97 | EPHX1 (0.41) | EPHX1SMN1; SMN2GAANPC1HTT | |
| SCHEMBL4078142 | 0.87 | EPHX1 (0.42) | EPHX1SMN1; SMN2GAANPC1HTT | |
| SCHEMBL17152289 | 0.86 | OPRK1 (0.34) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17152280 | 0.85 | EPHX2 (0.35) | EPHX2ALDH1A1 | |
| SCHEMBL17152226 | 0.84 | ALDH1A1 (0.41) | ALDH1A1 | |
| SCHEMBL17152404 | 0.83 | SMN1; SMN2 (0.43) | EPHX1SMN1; SMN2GAAEPHX2ALDH1A1 | |
| SCHEMBL17152502 | 0.82 | PARP1 (0.41) | SMN1; SMN2NPC1RAB9AEPHX2ALDH1A1 | |
| SCHEMBL17152590 | 0.81 | MEN1 (0.40) | ALDH1A1 | |
| SCHEMBL17152152 | 0.81 | MEN1 (0.40) | ALDH1A1 | |
| SCHEMBL17152489 | 0.81 | KMT2A (0.44) | EPHX1SMN1; SMN2EPHX2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |
| EP-2897939-A1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES AS APJ RECEPTOR MODULATORS | SANOFI (FR) | 2015-07-29 | — | — | EP | disclosed |
| WO-2014044738-A1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES AS APJ RECEPTOR MODULATORS | SANOFI (FR) | 2014-03-27 | — | — | WO | disclosed |