Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR4 | Q13639 | 4/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17152590 | 1.00 | MEN1 (0.40) | MEN1KMT2AL3MBTL1HTR4TMEM97 | |
| SCHEMBL17152226 | 0.95 | ALDH1A1 (0.41) | MEN1KMT2AHTR3AALDH1A1 | |
| SCHEMBL17152280 | 0.82 | EPHX2 (0.35) | SIGMAR1ALDH1A1 | |
| SCHEMBL15618596 | 0.81 | EPHX1 (0.38) | ALDH1A1 | |
| SCHEMBL17152483 | 0.81 | EPHX1 (0.41) | ALDH1A1CYP3A4 | |
| SCHEMBL17152489 | 0.77 | KMT2A (0.44) | MEN1KMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL17152289 | 0.77 | OPRK1 (0.34) | — | |
| SCHEMBL17152404 | 0.77 | SMN1; SMN2 (0.43) | MEN1KMT2AL3MBTL1HTR4ALDH1A1 | |
| SCHEMBL17152502 | 0.76 | PARP1 (0.41) | HTR4ALDH1A1 | |
| SCHEMBL9366512 | 0.73 | MEN1 (0.51) | MEN1KMT2AL3MBTL1HTR4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897939-B1 | BENZOIMIDAZOLE-CARBOXYLIC ACID AMIDE DERIVATIVES FOR TREATING METABOLIC OR CARDIOVASCULAR DISEASES | SANOFI SA (FR) | 2017-02-01 | — | — | EP | disclosed |
| US-9156796-B2 | Benzoimidazole-carboxylic acid amide derivatives as APJ receptor modulators | SANOFI (FR) | 2015-10-13 | — | — | US | disclosed |