Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | ALPG | P10696 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15630618 | 0.81 | LMNA (0.56) | LMNAALPGHTTMAPTHPGD | |
| SCHEMBL29738633 | 0.80 | CYP1A2 (0.53) | LMNAALPGHTTMAPTHPGD | |
| SCHEMBL6011707 | 0.80 | IDO1 (0.55) | LMNAALPGHTTHPGDUSP2 | |
| SCHEMBL6926139 | 0.80 | TAAR1 (0.54) | IDO1CYP1A2CYP2C19CYP2D6CYP3A4 | |
| SCHEMBL30753724 | 0.80 | IDO1 (0.50) | HTTTP53HPGDIDO1ALDH1A1 | |
| SCHEMBL10501653 | 0.76 | DRD2 (0.58) | LMNAMAPTTHRBCNR1ALOX12 | |
| SCHEMBL2303570 | 0.76 | DRD2 (0.54) | LMNAMAPTTDP1THRBCNR1 | |
| SCHEMBL487139 | 0.75 | ALDH1A1 (0.55) | HTTTP53HPGDIDO1ALDH1A1 | |
| SCHEMBL3674399 | 0.75 | CYP1A2 (0.63) | LMNAHPGDIDO1CYP1A2CYP2C19 | |
| SCHEMBL166370 | 0.73 | MEN1 (0.67) | LMNAHTTMAPTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110776447-A | Substituted alkyl diaryl derivatives, preparation method and use | 坦普尔大学 | 2020-02-11 | — | — | CN | claimed |
| US-20150266819-A1 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2015-09-24 | — | — | US | claimed |
| EP-2897599-A2 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | Temple University - Of The Commonwealth System of Higher Education (US) | 2015-07-29 | — | — | EP | claimed |
| WO-2014047110-A2 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-03-27 | — | — | WO | claimed |
| EP-2897599-B1 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | UNIV TEMPLE (US) | 2020-12-30 | — | — | EP | disclosed |
| EP-2897599-B1 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | UNIV TEMPLE (US) | 2020-12-30 | — | — | EP | disclosed |
| CN-110776447-A | Substituted alkyl diaryl derivatives, preparation method and use | 坦普尔大学 | 2020-02-11 | — | — | CN | disclosed |
| US-10207989-B2 | Substituted alkyl diaryl derivatives, methods of preparation and uses | Temple University—Of the Commonwealth System of Higher Education (US) | 2019-02-19 | — | — | US | disclosed |
| US-10207989-B2 | Substituted alkyl diaryl derivatives, methods of preparation and uses | Temple University—Of the Commonwealth System of Higher Education (US) | 2019-02-19 | — | — | US | disclosed |
| US-20150266819-A1 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2015-09-24 | — | — | US | disclosed |
| US-20150266819-A1 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2015-09-24 | — | — | US | disclosed |
| US-20150266819-A1 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2015-09-24 | — | — | US | disclosed |
| EP-2897599-A2 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | Temple University - Of The Commonwealth System of Higher Education (US) | 2015-07-29 | — | — | EP | disclosed |
| WO-2014047110-A2 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2014-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266819-A1 | SUBSTITUTED ALKYL DIARYL DERIVATIVES, METHODS OF PREPARATION AND USES | CCNY, CCNB3, BOD1L1 | LMNA 145/4885ALPG 1356/4885HTT 3545/4885 |
| US-10207989-B2 | Substituted alkyl diaryl derivatives, methods of preparation and uses | CCNY, CCNB3, BOD1L1 | LMNA 145/4885ALPG 1356/4885HTT 3545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.