Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.46 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.44 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562282 | 1.00 | MAOB (0.48) | MAOBCYP3A4DPP4TTRCA12 | |
| SCHEMBL11225538 | 0.85 | CNKSR1 (0.49) | MAOBCYP3A4DPP4TTRCA12 | |
| SCHEMBL11225533 | 0.85 | CNKSR1 (0.49) | MAOBCYP3A4DPP4TTRCA12 | |
| SCHEMBL19257215 | 0.83 | MAOB (0.48) | MAOBCYP3A4DPP4TTRCA12 | |
| SCHEMBL11970741 | 0.82 | NFKB1 (0.55) | CYP3A4DPP4CA2ALOX5AKT1 | |
| SCHEMBL11970736 | 0.82 | NFKB1 (0.55) | CYP3A4DPP4CA2ALOX5AKT1 | |
| SCHEMBL435330 | 0.82 | MAOB (0.49) | MAOBCYP3A4DPP4TTRCA12 | |
| SCHEMBL18260176 | 0.79 | CA12 (0.51) | MAOBCYP3A4DPP4TTRCA12 | |
| SCHEMBL13324262 | 0.77 | CA12 (0.51) | MAOBCYP3A4DPP4TTRCA12 | |
| SCHEMBL13091485 | 0.77 | CA12 (0.51) | MAOBCYP3A4DPP4TTRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805160-B1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | LILLY CO ELI (US) | 2011-04-06 | — | — | EP | disclosed |
| EP-1805160-B1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | LILLY CO ELI (US) | 2011-04-06 | — | — | EP | disclosed |
| US-7354951-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354951-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2008-04-08 | — | — | US | disclosed |
| US-7354951-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2008-04-08 | — | — | US | disclosed |
| US-20080064742-A1 | Substituted Benzopyrans as Selective Estrogen Receptor-Beta Agonists | ELI LILLY AND COMPANY | 2008-03-13 | — | — | US | disclosed |
| US-20080064742-A1 | Substituted Benzopyrans as Selective Estrogen Receptor-Beta Agonists | ELI LILLY AND COMPANY | 2008-03-13 | — | — | US | disclosed |
| US-20080064742-A1 | Substituted Benzopyrans as Selective Estrogen Receptor-Beta Agonists | ELI LILLY AND COMPANY | 2008-03-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064742-A1 | Substituted Benzopyrans as Selective Estrogen Receptor-Beta Agonists | ESR2, GPER1, ESR1 | MAOB 1276/4885CYP3A4 1075/4885DPP4 2424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.