Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MPO | P05164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6751703 | 0.94 | ATM (0.41) | SIGMAR1ATML3MBTL1MEN1KMT2A | |
| SCHEMBL31402003 | 0.86 | MEN1 (0.43) | SIGMAR1ATML3MBTL1MEN1KMT2A | |
| SCHEMBL2062907 | 0.86 | MEN1 (0.43) | SIGMAR1ATML3MBTL1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27623677 | 0.84 | MEN1 (0.42) | SIGMAR1ATML3MBTL1MEN1KMT2A | |
| SCHEMBL23159850 | 0.83 | ALOX15 (0.47) | SIGMAR1L3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL23159817 | 0.81 | SIGMAR1 (0.46) | SIGMAR1L3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL23159894 | 0.79 | ALOX15 (0.47) | SIGMAR1L3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL29720312 | 0.77 | TAAR1 (0.48) | ATML3MBTL1HIF1AEPAS1TBXAS1 | |
| SCHEMBL7006141 | 0.77 | MPO (0.49) | HIF1AKDM4EMPOSLC6A4 | |
| SCHEMBL30929931 | 0.77 | SIGMAR1 (0.46) | SIGMAR1L3MBTL1MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2845592-A1 | Benzoxazepin PI3K inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2015-03-11 | — | — | EP | disclosed |
| EP-2711368-A1 | Benzoxazepin PI3K inhibitor compounds and methods of use | F. Hoffmann-La Roche AG (CH) | 2014-03-26 | — | — | EP | disclosed |