Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 17/20 | 0.60 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.56 |
| ▸ | RORA | P35398 | 4/20 | 0.56 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.56 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.56 |
| ▸ | RORB | Q92753 | 4/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18359195 | 0.91 | RORC (0.61) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL15628993 | 0.82 | RORC (0.65) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL15628949 | 0.81 | RORC (0.66) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL15629063 | 0.81 | RORC (0.62) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL15629002 | 0.80 | RORC (0.65) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL18359159 | 0.79 | RORC (0.61) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL18359167 | 0.79 | RORC (0.62) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL18359194 | 0.79 | RORC (0.60) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL5021848 | 0.77 | RORC (0.87) | RORCNR1I2RORANR1H2NR1H3 | |
| SCHEMBL16823760 | 0.77 | RORC (0.80) | RORCNR1I2RORANR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9512111-B2 | N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of RORγ activity and the treatment of disease | LYCERA CORPORATION (US) | 2016-12-06 | — | — | US | disclosed |
| US-20140088094-A1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | MERCK SHARP & DOHME CORP. (US) | 2014-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140088094-A1 | N-SULFONYLATED TETRAHYDROQUINOLINES AND RELATED BICYCLIC COMPOUNDS FOR INHIBITION OF RORgamma ACTIVITY AND THE TREATMENT OF DISEASE | RORC, RORB, RORA | RORC 1/4885NR1I2 9/4885RORA 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.