Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 6/20 | 0.60 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.53 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.48 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.45 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1562834 | 0.86 | CHEK1 (0.71) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL27657374 | 0.86 | CHEK1 (0.71) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL1563670 | 0.85 | USP30 (0.68) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL1563523 | 0.85 | USP30 (0.63) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL1563534 | 0.84 | CHEK1 (0.68) | USP30CHEK1CDK2AP1 | |
| SCHEMBL1564584 | 0.82 | USP30 (0.64) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL4991807 | 0.79 | CHEK1 (0.61) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL1562875 | 0.79 | USP30 (0.57) | USP30CHEK1ACKR3PARP1PBK | |
| SCHEMBL4219757 | 0.77 | CHEK1 (0.59) | USP30CHEK1PARP1CDK2AP1 | |
| SCHEMBL4994947 | 0.77 | CHEK1 (0.59) | USP30CHEK1PARP1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100584840-C | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB | 2010-01-27 | — | — | CN | disclosed |
| CN-1922172-A | Substituted heterocyclic compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-02-28 | — | — | CN | disclosed |