Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | CES2 | O00748 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.49 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13127271 | 0.78 | CES2 (0.55) | KMT2ALMNANAPRTP4HTML3MBTL1 | |
| SCHEMBL2006799 | 0.77 | CES2 (0.64) | KMT2AAGTR1LMNANAPRTP4HTM | |
| SCHEMBL28250849 | 0.76 | CES1 (0.48) | KMT2ALMNANAPRTL3MBTL1CES2 | |
| SCHEMBL322444 | 0.76 | AGTR1 (0.58) | KMT2AAGTR1LMNANAPRTP4HTM | |
| SCHEMBL3777401 | 0.76 | LMNA (0.61) | KMT2AAGTR1LMNANAPRTP4HTM | |
| SCHEMBL11768655 | 0.76 | AGTR1 (0.58) | KMT2AAGTR1LMNANAPRTP4HTM | |
| SCHEMBL29498791 | 0.76 | AGTR1 (0.58) | KMT2AAGTR1LMNANAPRTP4HTM | |
| SCHEMBL322443 | 0.76 | AGTR1 (0.58) | KMT2AAGTR1LMNANAPRTP4HTM | |
| SCHEMBL398165 | 0.75 | KMT2A (1.00) | KMT2AAGTR1LMNANAPRTP4HTM | |
| SCHEMBL29373829 | 0.75 | KMT2A (1.00) | KMT2AAGTR1LMNANAPRTP4HTM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903989-A1 | PYRROLO[2,3-D]PYRIMIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | Pfizer Limited (GB) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014053967-A1 | PYRROLO[2,3-D]PYRIMIDINE TROPOMYOSIN-RELATED KINASE INHIBITORS | PFIZER LIMITED (GB) | 2014-04-10 | — | — | WO | disclosed |