Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15639471 | 0.84 | KMT2A (0.41) | ALDH1A1MAP2K1MAP2K2NPC1RAB9A | |
| SCHEMBL15638942 | 0.79 | HDAC1 (0.42) | ALDH1A1SOS1CYP2D6CYP2C19NPC1 | |
| SCHEMBL29581577 | 0.77 | ALDH1A1 (0.47) | ALDH1A1SOS1CYP2D6CYP2C19NPC1 | |
| SCHEMBL3606443 | 0.77 | ALDH1A1 (0.47) | ALDH1A1SOS1CYP2D6CYP2C19NPC1 | |
| SCHEMBL9535914 | 0.76 | MAP2K1 (0.47) | ALDH1A1SOS1MAP2K1CYP2D6CYP2C19 | |
| SCHEMBL9535897 | 0.75 | HDAC1 (0.50) | ALDH1A1SOS1CYP2C19NPC1RAB9A | |
| SCHEMBL20155425 | 0.75 | SOS1 (0.46) | ALDH1A1SOS1CYP2D6CYP2C19NPC1 | |
| SCHEMBL9538256 | 0.74 | HDAC1 (0.49) | ALDH1A1CYP2C19NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11901667 | 0.74 | CCNC (0.50) | ALDH1A1CYP2D6CYP2C19NPC1RAB9A | |
| SCHEMBL20155496 | 0.73 | SOS1 (0.42) | ALDH1A1SOS1CYP2D6CYP2C19NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903980-B1 | BENZIMIDAZOLES AS CNS ACTIVE AGENTS | HOFFMANN LA ROCHE (CH) | 2017-07-19 | — | — | EP | disclosed |
| US-9365550-B2 | Benzimidazoles as CNS active agents | HOFFMANN-LA ROCHE INC. (US) | 2016-06-14 | — | — | US | disclosed |
| EP-2903980-A1 | BENZIMIDAZOLES AS CNS ACTIVE AGENTS | F. Hoffmann-La Roche AG (CH) | 2015-08-12 | — | — | EP | disclosed |
| US-20150203472-A1 | BENZIMIDAZOLES AS CNS ACTIVE AGENTS | HOFFMANN-LA ROCHE INC. (US) | 2015-07-23 | — | — | US | disclosed |
| WO-2014053409-A1 | BENZIMIDAZOL.ES AS CNS ACTIVE AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150203472-A1 | BENZIMIDAZOLES AS CNS ACTIVE AGENTS | CDR2, HTR2B, HCRTR1 | ALDH1A1 539/4885SOS1 2133/4885MAP2K1 2094/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.