Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15647563 | 1.00 | MAPT (0.46) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL1014326 | 0.86 | CYP2C9 (0.46) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL1014327 | 0.86 | CYP2C9 (0.46) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL31587550 | 0.86 | CYP2C9 (0.46) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL20428017 | 0.84 | HPGD (0.45) | MAPTGAAALDH1A1MEN1KMT2A | |
| SCHEMBL28228568 | 0.83 | CYP2C9 (0.44) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL30550006 | 0.83 | CYP2C9 (0.44) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL24863517 | 0.76 | CYP2C9 (0.43) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL17091895 | 0.75 | CYP2C9 (0.38) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 | |
| SCHEMBL15647706 | 0.75 | CYP2C9 (0.38) | MAPTGAAALDH1A1CYP2C9SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10035790-B2 | RORγ modulators | EXELIXIS, INC. (US) | 2018-07-31 | — | — | US | disclosed |
| US-20150266856-A1 | RORGamma Modulators | EXELIXIS, INC. | 2015-09-24 | — | — | US | disclosed |
| WO-2014062938-A1 | RORY MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150266856-A1 | RORGamma Modulators | RORB, RORA, RORC | MAPT 3021/4885GAA 2229/4885ALDH1A1 1877/4885 |
| US-10035790-B2 | RORγ modulators | RORB, RORA, RORC | MAPT 3030/4885GAA 2832/4885ALDH1A1 1669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.