Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | P2RY1 | P47900 | 5/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15663526 | 0.87 | GRM5 (0.40) | GRM5 | |
| SCHEMBL15663761 | 0.84 | GRM5 (0.52) | GRM5KMT2AHTT | |
| SCHEMBL15663889 | 0.83 | GRM5 (0.35) | LPAR1GRM5MAPTTGFBR1KMT2A | |
| SCHEMBL15664001 | 0.81 | PDE4B (0.40) | LPAR1GRM5MAPTKMT2AHTT | |
| SCHEMBL15663531 | 0.80 | PDE10A (0.40) | GRM5 | |
| SCHEMBL15663466 | 0.79 | SMARCA2 (0.42) | LPAR1GRM5KMT2ANPC1RAB9A | |
| SCHEMBL15664381 | 0.78 | NPC1 (0.42) | GRM5MAPTL3MBTL1HTTNPC1 | |
| SCHEMBL15663677 | 0.72 | GRM5 (0.54) | GRM5 | |
| SCHEMBL2827599 | 0.71 | GRM5 (0.46) | GRM5NTRK1KMT2ANPC1RAB9A | |
| SCHEMBL15663522 | 0.71 | GRM5 (0.40) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1858854-B1 | PYRIDINE-2-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2014-05-07 | — | — | EP | claimed |