Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2826109 | 0.87 | GRM5 (0.47) | GRM5KMT2ARAB9AASIC3NPC1 | |
| SCHEMBL2826591 | 0.86 | GRM5 (0.46) | GRM5KMT2ANTRK1RAB9ANPC1 | |
| SCHEMBL2830506 | 0.83 | GRM5 (0.48) | GRM5KMT2ARAB9ANPC1TP53 | |
| SCHEMBL2830193 | 0.83 | GRM5 (0.51) | GRM5NTRK1 | |
| SCHEMBL2826581 | 0.83 | GRM5 (0.50) | GRM5KMT2ARAB9ANPC1 | |
| SCHEMBL2830131 | 0.83 | GRM5 (0.49) | GRM5KMT2ANTRK1RAB9ANPC1 | |
| SCHEMBL2830253 | 0.82 | GRM5 (0.51) | GRM5KMT2ARAB9ANPC1 | |
| SCHEMBL2824785 | 0.82 | GRM5 (0.70) | GRM5KMT2ARAB9ANPC1 | |
| SCHEMBL2830047 | 0.80 | SMARCA2 (0.41) | GRM5NTRK1RAB9ANPC1 | |
| SCHEMBL2829267 | 0.79 | GRM5 (0.55) | GRM5KMT2ARAB9ANPC1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1844044-B1 | THIAZOLE-4-CARBOXAMIDE DERIVATIVES AS MGLUR5 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-07-21 | — | — | EP | claimed |