Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ABCC1 | P33527 | 8/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14488466 | 0.95 | HTR1A (0.46) | HTR1ASIGMAR1CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL14488276 | 0.91 | ABCC1 (0.45) | HTR1ACYP3A4ABCC1 | |
| SCHEMBL14488210 | 0.84 | HTR1A (0.48) | HTR1ASIGMAR1CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL14486417 | 0.83 | HTR1A (0.42) | HTR1ASIGMAR1HTR2CDRD2HTR2A | |
| SCHEMBL14486076 | 0.82 | SIGMAR1 (0.49) | HTR1ASIGMAR1TDP1DRD2HTR2A | |
| SCHEMBL14486854 | 0.82 | HTR1A (0.48) | HTR1ASIGMAR1CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL14486750 | 0.81 | SMYD2 (0.42) | HTR1ASIGMAR1CYP3A4TDP1DRD2 | |
| SCHEMBL14486543 | 0.81 | HTR1A (0.48) | HTR1ASIGMAR1CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL14488214 | 0.80 | HTR1A (0.44) | HTR1ASIGMAR1CYP3A4ALDH1A1CYP1A2 | |
| SCHEMBL14488568 | 0.79 | FAAH (0.48) | HTR1ASIGMAR1CYP3A4ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140128404-A1 | 1, 2, 4-Thiadiazol-5-Ylpiperazine derivatives useful in the treatment of neurodegenerative diseases | REMYND NV (BE) | 2014-05-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128404-A1 | 1, 2, 4-Thiadiazol-5-Ylpiperazine derivatives useful in the treatment of neurodegenerative diseases | MAPT, PSEN1, PSEN2 | HTR1A 1628/4885SIGMAR1 2467/4885CYP3A4 3554/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.