Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.46 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3775280 | 0.84 | HDAC1 (0.56) | KMT2AHDAC1MKNK1MKNK2ALDH1A1 | |
| SCHEMBL25378385 | 0.78 | KMT2A (0.58) | KMT2AHDAC1ALDH1A1NAPRTGAA | |
| SCHEMBL30482084 | 0.78 | KMT2A (0.58) | KMT2AHDAC1ALDH1A1NAPRTGAA | |
| SCHEMBL28596953 | 0.78 | HDAC1 (0.56) | KMT2AHDAC1ALDH1A1NAPRTPKM | |
| SCHEMBL5353235 | 0.78 | TBXAS1 (0.62) | MKNK1MKNK2ALDH1A1NAPRTGAA | |
| Aminomethylbenzoic Acid SCHEMBL5211981 | 0.78 | MKNK1 (0.54) | MKNK1MKNK2ALDH1A1NAPRTGAA | |
| SCHEMBL1566548 | 0.78 | HDAC1 (0.58) | KMT2AHDAC1 | |
| SCHEMBL8996251 | 0.77 | TBXAS1 (0.58) | KMT2AMKNK1MKNK2ALDH1A1NAPRT | |
| SCHEMBL11067952 | 0.77 | TBXAS1 (0.67) | MKNK1MKNK2ALDH1A1NAPRTGAA | |
| SCHEMBL20236358 | 0.77 | POLB (0.50) | KMT2AHDAC1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889876-B2 | Histone deacetylase inhibitors and uses thereof | JIANGSU HENGYI PHARMACEUTICAL CO., LTD. (CN) | 2014-11-18 | — | — | US | disclosed |
| US-20110152323-A1 | Histone deacetylase inhibitors and uses thereof | JIANGSU GOWORTH INVESTMENT CO. LTD (CN) | 2011-06-23 | — | — | US | disclosed |
| EP-2308868-A1 | HISTONE DEACETYLASE INHIBITORS AND USES THEREOF | Jiangsu Goworth Investment Co. Ltd (CN) | 2011-04-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152323-A1 | Histone deacetylase inhibitors and uses thereof | HDAC1, HDAC11, HDAC5 | KMT2A 45/4885HDAC1 1/4885MKNK1 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.