Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30268624 | 0.86 | ALOX15 (0.62) | ALOX5ALOX15ESR2HSD17B10APP | |
| SCHEMBL5028631 | 0.86 | ALOX15 (0.62) | ALOX5ALOX15ESR2HSD17B10APP | |
| SCHEMBL9622875 | 0.82 | ALOX5 (0.62) | ALOX5ALOX15ESR2APPKMT2A | |
| SCHEMBL3339161 | 0.82 | ALOX15 (0.65) | ALOX5ALOX15ESR2HSD17B10APP | |
| SCHEMBL91153 | 0.81 | — | — | |
| SCHEMBL29629596 | 0.81 | — | — | |
| SCHEMBL1371332 | 0.80 | ALOX5 (0.64) | ALOX5ALOX15ESR2HSD17B10APP | |
| SCHEMBL30144854 | 0.80 | ALOX5 (0.64) | ALOX5ALOX15ESR2HSD17B10APP | |
| SCHEMBL28708943 | 0.79 | ALOX15 (0.54) | ALOX5ALOX15HSD17B10TSHRCYP19A1 | |
| SCHEMBL28686760 | 0.79 | ALOX15 (0.54) | ALOX5ALOX15HSD17B10TSHRCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917181-B1 | HETEROARYL DERIVATIVES AND USES THEREOF | JACOBUS PHARMACEUTICAL COMPANY INC (US) | 2019-09-25 | — | — | EP | disclosed |
| US-9409893-B2 | Heteroaryl derivatives and uses thereof | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2016-08-09 | — | — | US | disclosed |
| EP-2917181-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | Jacobus Pharmaceutical Company, Inc. (US) | 2015-09-16 | — | — | EP | disclosed |
| WO-2014074775-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2014-05-15 | — | — | WO | disclosed |
| US-20140135320-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | JACOBUS PHARMACEUTICAL COMPANY, INC. (US) | 2014-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140135320-A1 | HETEROARYL DERIVATIVES AND USES THEREOF | ABCC1, CYP3A43, ABCB1 | ALOX5 1202/4885ALOX15 2197/4885ESR2 4506/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.