Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | MST1R | Q04912 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842620 | 0.83 | ACHE (0.54) | ACHEPARP1DRD1KDM4ERECQL | |
| SCHEMBL15680365 | 0.71 | CLK1 (0.40) | ACHEPIK3CDPIK3CBPIK3CAPIM1 | |
| SCHEMBL29531520 | 0.70 | PIK3CD (0.53) | ACHEPIK3CDPIK3CBPIK3CACDK5 | |
| SCHEMBL31158620 | 0.69 | CLK4 (0.44) | ACHEPIK3CDPIK3CBPIK3CACDK5 | |
| SCHEMBL30402278 | 0.69 | ACHE (0.50) | ACHEPARP1KDM4EHSD17B10MAPT | |
| SCHEMBL10129821 | 0.69 | ACHE (0.50) | ACHEPARP1KDM4EHSD17B10MAPT | |
| SCHEMBL11450232 | 0.68 | CDK5 (0.47) | ACHEPIK3CDPIK3CBPIK3CACDK5 | |
| SCHEMBL11346836 | 0.68 | MEN1 (0.44) | CDK5DYRK1ACLK4PIM1CSNK1A1 | |
| SCHEMBL15680317 | 0.68 | ACHE (0.68) | ACHEPIK3CDPIK3CBPIK3CACDK5 | |
| SCHEMBL15680228 | 0.68 | ALOX5 (0.36) | PIM1KDRMETALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014068388-A1 | 2 SUBSTITUTED CEPHEM COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2014-05-08 | — | — | WO | disclosed |