Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 20/20 | 0.69 |
| ▸ | TRPV4 | Q9HBA0 | 10/20 | 0.65 |
| ▸ | TRPV3 | Q8NET8 | 4/20 | 0.63 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL612025 | 0.93 | TRPA1 (0.75) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL611669 | 0.89 | TRPA1 (0.76) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL612877 | 0.86 | TRPA1 (0.72) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL14227827 | 0.86 | TRPA1 (0.87) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL609319 | 0.85 | TRPA1 (0.78) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL14227824 | 0.85 | TRPA1 (0.86) | TRPA1TRPV4TRPV3TRPV1 | |
| SCHEMBL611387 | 0.83 | TRPA1 (0.78) | TRPA1TRPV4TRPV3 | |
| SCHEMBL612545 | 0.83 | TRPA1 (0.71) | TRPA1TRPV4TRPV3 | |
| SCHEMBL608603 | 0.82 | TRPA1 (1.00) | TRPA1TRPV4TRPV3 | |
| SCHEMBL13190821 | 0.80 | TRPA1 (0.71) | TRPA1TRPV4TRPV3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9000159-B2 | Fused pyrimidine-dione derivatives as TRPA1 modulators | GLENMARK PHARMACEUTICALS S.A. (CH) | 2015-04-07 | — | — | US | disclosed |
| US-20140128603-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS, S.A. (CH) | 2014-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128603-A1 | FUSED PYRIMIDINE-DIONE DERIVATIVES AS TRPA1 MODULATORS | TRPA1, TRPV1, TRPV2 | TRPA1 1/4885TRPV4 8/4885TRPV3 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.