Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28321971 | 0.80 | TRPA1 (0.42) | TSHRTRPA1ALDH1A1MAPTHTT | |
| SCHEMBL11099247 | 0.80 | ALDH1A1 (0.30) | ALDH1A1MAPT | |
| SCHEMBL28515424 | 0.76 | TSHR (0.50) | TSHRTRPA1ALDH1A1MAPTHTT | |
| SCHEMBL9493266 | 0.72 | TSHR (0.46) | TSHRTRPA1ALDH1A1MAPTHTT | |
| SCHEMBL28929083 | 0.72 | TSHR (0.46) | TSHRTRPA1ALDH1A1MAPTHTT | |
| SCHEMBL22190304 | 0.72 | TSHR (0.40) | TSHRALDH1A1TAAR1DPP4 | |
| SCHEMBL28518519 | 0.71 | PTGS2 (0.37) | TSHRTRPA1ALDH1A1MAPTCTSL | |
| SCHEMBL1021030 | 0.68 | TSHR (0.46) | TSHRTRPA1ALDH1A1MAPTHTT | |
| SCHEMBL2155150 | 0.68 | TSHR (0.44) | TSHRALDH1A1TAAR1DPP4 | |
| SCHEMBL31130672 | 0.68 | SRC (0.39) | TSHRLMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307397-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | Array Biopharma, Inc. (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009158426-A1 | 6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES | ARRAY BIOPHARMA INC. (US) | 2009-12-30 | — | — | WO | disclosed |
| EP-0066482-B1 | METHOD FOR THE PREPARATION OF ALIPHATIC OR AROMATIC NITRILES | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-11-28 | — | — | EP | disclosed |
| EP-0065447-B1 | FLUOR-CONTAINING SILICA CATALYSTS; THEIR PREPARATION, AND THEIR USE IN THE PREPARATION OF NITRILES | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1984-09-05 | — | — | EP | disclosed |
| EP-0066482-A1 | Method for the preparation of aliphatic or aromatic nitriles | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1982-12-08 | — | — | EP | disclosed |
| EP-0066483-A1 | Method for the preparation of aliphatic or aromatic nitriles | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1982-12-08 | — | — | EP | disclosed |
| EP-0065447-A1 | Fluor-containing silica catalysts; their preparation, and their use in the preparation of nitriles | RHONE-POULENC SPECIALITES CHIMIQUES (FR) | 1982-11-24 | — | — | EP | disclosed |