Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6052893 | 0.91 | GBA2 (0.45) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL6819738 | 0.91 | GBA2 (0.45) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL25348025 | 0.91 | GBA2 (0.47) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL15715217 | 0.91 | GBA2 (0.47) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL17154832 | 0.87 | LMNA (0.43) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL17674467 | 0.84 | GBA2 (0.44) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL26727695 | 0.83 | ALDH1A1 (0.39) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4319323 | 0.82 | LMNA (0.36) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL4748921 | 0.81 | LMNA (0.46) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL7455919 | 0.81 | LMNA (0.43) | GBA2LMNAPOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9605022-B2 | Macrocyclic compounds for inhibition of inhibitors of apoptosis | ENSEMBLE THERAPEUTICS CORPORATION (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150284427-A1 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-10-08 | — | — | US | disclosed |
| WO-2014074665-A1 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150284427-A1 | MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS | BAX, API5, BCL2 | GBA2 3519/4885LMNA 303/4885POLB 2108/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.