Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TYMS | P04818 | 11/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.39 |
| ▸ | HTR3B | O95264 | 1/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5683322 | 0.81 | ALDH1A1 (0.49) | ALDH1A1TDP1TYMSMEN1USP2 | |
| SCHEMBL8855514 | 0.78 | ALDH1A1 (0.39) | ALDH1A1MEN1KMT2ANPBWR1GRIN2D | |
| SCHEMBL7045265 | 0.74 | HTR3E (0.47) | ALDH1A1TDP1TYMSHTR3EHTR3B | |
| Methane SCHEMBL6992410 | 0.73 | MMP2 (0.50) | ALDH1A1MEN1KMT2ANPBWR1NPC1 | |
| SCHEMBL18055756 | 0.72 | EPAS1 (0.60) | TYMS | |
| SCHEMBL6579702 | 0.72 | ALDH1A1 (0.48) | ALDH1A1TDP1TYMSDHFRNPC1 | |
| SCHEMBL27759850 | 0.71 | HTR3E (0.44) | ALDH1A1TYMSHTR3EHTR3BHTR3A | |
| SCHEMBL1201707 | 0.71 | TYMS (0.56) | ALDH1A1TDP1TYMSMEN1KMT2A | |
| SCHEMBL15716836 | 0.71 | CYP3A4 (0.46) | ALDH1A1TDP1MEN1KMT2AMAPT | |
| SCHEMBL15716960 | 0.71 | TSHR (0.36) | ALDH1A1TDP1MEN1USP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9757379-B2 | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-09-12 | — | — | US | disclosed |
| US-9757379-B2 | Inhibition of HIF-2α heterodimerization with HIF1β (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2017-09-12 | — | — | US | disclosed |
| US-20160250216-A1 | INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-09-01 | — | — | US | disclosed |
| US-20160250216-A1 | INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-09-01 | — | — | US | disclosed |
| EP-2919770-A2 | INHIBITION OF HIF-2 HETERODIMERIZATION WITH HIF1 (ARNT) | The Board of Regents of The University of Texas System (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014078479-A2 | INHIBITION OF HIF-2α HETERODIMERIZATION WITH HIF1β (ARNT) | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160250216-A1 | INHIBITION OF HIF-2ALPHA HETERODIMERIZATION WITH HIF1BETA (ARNT) | HIF1AN, HIF1A, EGLN2 | ALDH1A1 1277/4885TDP1 4633/4885TYMS 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.