Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 13/20 | 1.00 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAT2A | P31153 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15720725 | 0.90 | TRPA1 (1.00) | TRPA1TOP2AADRA1BMEN1ALDH1A1 | |
| SCHEMBL15720584 | 0.87 | TRPA1 (1.00) | TRPA1TOP2AADRA1BMEN1ALDH1A1 | |
| SCHEMBL15720677 | 0.85 | TRPA1 (1.00) | TRPA1TOP2AADRA1BMEN1ALDH1A1 | |
| SCHEMBL15740030 | 0.85 | TRPA1 (1.00) | TRPA1TOP2AADRA1BMEN1ALDH1A1 | |
| SCHEMBL15720556 | 0.84 | TRPA1 (1.00) | TRPA1TOP2AADRA1BMEN1ALDH1A1 | |
| SCHEMBL15720616 | 0.78 | TRPA1 (1.00) | TRPA1TOP2AADRA1BMEN1ALDH1A1 | |
| SCHEMBL15719501 | 0.76 | TRPA1 (1.00) | TRPA1 | |
| SCHEMBL17052784 | 0.75 | TRPA1 (0.76) | TRPA1TOP2AADRA1BMEN1ALDH1A1 | |
| SCHEMBL18003005 | 0.73 | ALDH1A3 (0.64) | TRPA1ALDH1A1MAPTMAT2A | |
| SCHEMBL15720379 | 0.70 | TRPA1 (1.00) | TRPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9394304-B2 | Imidazopyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-07-19 | — | — | US | claimed |
| EP-2920169-A1 | IMIDAZOPYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-09-23 | — | — | EP | claimed |
| US-20150246918-A1 | IMIDAZOPYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | claimed |
| WO-2014076021-A1 | IMIDAZOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-22 | — | — | WO | claimed |
| US-9394304-B2 | Imidazopyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394304-B2 | Imidazopyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9394304-B2 | Imidazopyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-07-19 | — | — | US | disclosed |
| EP-2920169-A1 | IMIDAZOPYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-09-23 | — | — | EP | disclosed |
| US-20150246918-A1 | IMIDAZOPYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | disclosed |
| US-20150246918-A1 | IMIDAZOPYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | disclosed |
| US-20150246918-A1 | IMIDAZOPYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-09-03 | — | — | US | disclosed |
| WO-2014076021-A1 | IMIDAZOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-22 | — | — | WO | disclosed |
| WO-2014076021-A1 | IMIDAZOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150246918-A1 | IMIDAZOPYRIDINE DERIVATIVES | QDPR, ADRB3, HRH4 | TRPA1 882/4885TOP2A 1652/4885ADRA1B 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.