Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFD | P00746 | 7/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18549611 | 0.86 | CFD (0.32) | CFD | |
| SCHEMBL28712524 | 0.86 | CFD (0.32) | CFD | |
| SCHEMBL15720961 | 0.81 | TSHR (0.36) | MMP2ANPEPTSHRBRD4 | |
| SCHEMBL15719829 | 0.81 | MMP2 (0.33) | MMP2ANPEPTSHRBRD4 | |
| SCHEMBL15721076 | 0.77 | BRD4 (0.33) | CFDMMP2ANPEPTSHRBRD4 | |
| SCHEMBL12480627 | 0.73 | S1PR1 (0.41) | CFD | |
| SCHEMBL15718956 | 0.71 | BRD4 (0.34) | MMP2ANPEPTSHRBRD4 | |
| SCHEMBL15719780 | 0.71 | TSHR (0.36) | MMP2ANPEPTSHRBRD4 | |
| SCHEMBL2564045 | 0.70 | CYP2C19 (0.35) | MMP2ANPEPTSHRBRD4 | |
| SCHEMBL15719819 | 0.69 | TSHR (0.37) | MMP2ANPEPTSHRBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925741-A1 | PYRROLIDINE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014078609-A1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |