Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | HPGDS | O60760 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.34 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.34 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28301992 | 0.81 | PARP1 (0.43) | PARP1HPGDSCDC7PIM1CSNK2B | |
| SCHEMBL29407626 | 0.71 | CCNK (0.46) | — | |
| SCHEMBL17362591 | 0.68 | ALDH1A1 (0.36) | PARP1PBK | |
| SCHEMBL30515860 | 0.68 | EGFR (0.33) | DNMT1DNMT3B | |
| SCHEMBL4373720 | 0.68 | PARP1 (0.43) | PARP1HPGDS | |
| SCHEMBL28460425 | 0.67 | HRH4 (0.40) | PARP1HPGDS | |
| SCHEMBL160304 | 0.67 | ADORA2A (0.40) | MAP4K4 | |
| SCHEMBL42313 | 0.66 | ADORA2A (0.42) | MAP4K4 | |
| SCHEMBL22502512 | 0.66 | ADORA3 (0.37) | PARP1 | |
| SCHEMBL31670662 | 0.66 | ADORA3 (0.37) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920172-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | Merck Sharp & Dohme Corp. (US) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014075393-A1 | PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | MERCK SHARP & DOHME CORP. (US) | 2014-05-22 | — | — | WO | disclosed |