Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 16/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C8 | P10632 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15719398 | 0.90 | FFAR1 (0.45) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15719399 | 0.90 | FFAR1 (0.45) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15710212 | 0.83 | FFAR1 (0.52) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15710756 | 0.83 | FFAR1 (0.52) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL17239718 | 0.83 | FFAR1 (0.52) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15718551 | 0.83 | FFAR1 (0.52) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15710870 | 0.82 | FFAR1 (0.48) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15719954 | 0.82 | FFAR1 (0.41) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15720274 | 0.82 | FFAR1 (0.41) | FFAR1CYP3A4CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL15718957 | 0.79 | FFAR1 (0.46) | FFAR1CHRM4FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604964-B2 | Dihydropyrazole GPR40 modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2925749-B1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2016-10-26 | — | — | EP | disclosed |
| US-20160297797-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2016-10-13 | — | — | US | disclosed |
| EP-2925749-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | Bristol-Myers Squibb Company (US) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014078611-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297797-A1 | DIHYDROPYRAZOLE GPR40 MODULATORS | GPR55, GPR65, GPR35 | FFAR1 34/4885CYP3A4 650/4885CYP2C8 1339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.