Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.51 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.50 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14357537 | 0.99 | SIGMAR1 (0.52) | SIGMAR1NPFFR1NPFFR2ALDH1A1LMNA | |
| SCHEMBL30500906 | 0.91 | NPFFR1 (0.50) | SIGMAR1NPFFR1NPFFR2KMT2AMEN1 | |
| SCHEMBL10682348 | 0.85 | KMT2A (0.51) | SIGMAR1NPFFR1NPFFR2KMT2AL3MBTL1 | |
| SCHEMBL7239887 | 0.84 | SIGMAR1 (0.52) | SIGMAR1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL15709401 | 0.84 | SIGMAR1 (0.53) | SIGMAR1ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7238864 | 0.83 | SIGMAR1 (0.52) | SIGMAR1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL14290582 | 0.83 | OPRM1 (0.55) | SIGMAR1KMT2AL3MBTL1 | |
| SCHEMBL9091685 | 0.83 | OPRM1 (0.55) | SIGMAR1KMT2AL3MBTL1 | |
| Hydrochloric Acid SCHEMBL7234734 | 0.83 | SIGMAR1 (0.51) | SIGMAR1ALDH1A1LMNAL3MBTL1 | |
| SCHEMBL5431144 | 0.82 | SIGMAR1 (0.54) | SIGMAR1ALDH1A1LMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988388-B2 | Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof | UNIVERSITE DE BOURGOGNE (FR) | 2018-06-05 | — | — | US | disclosed |
| US-9988388-B2 | Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C- functionalized derivatives thereof | UNIVERSITE DE BOURGOGNE (FR) | 2018-06-05 | — | — | US | disclosed |
| US-9981967-B2 | Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof | UNIVERSITE DE BOURGOGNE (FR) | 2018-05-29 | — | — | US | disclosed |
| US-9981967-B2 | Synthesis of imidazo[1,2-a]pyrazin-4-ium salts for the synthesis of 1,4,7-triazacyclononane (tacn) and N- and/or C-functionalized derivatives thereof | UNIVERSITE DE BOURGOGNE (FR) | 2018-05-29 | — | — | US | disclosed |
| EP-2922830-B1 | SYNTHESIS OF IMIDAZO(1,2-A)PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF | UNIV BOURGOGNE (FR) | 2018-05-16 | — | — | EP | disclosed |
| US-20160222018-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C- FUNCTIONALIZED DERIVATIVES THEREOF | UNIVERSITE DE BOURGOGNE (FR) | 2016-08-04 | — | — | US | disclosed |
| US-20160222018-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C- FUNCTIONALIZED DERIVATIVES THEREOF | UNIVERSITE DE BOURGOGNE (FR) | 2016-08-04 | — | — | US | disclosed |
| WO-2014079953-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF | Université de Bourgogne (FR) | 2014-05-30 | — | — | WO | disclosed |
| US-20140142298-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2014-05-22 | — | — | US | disclosed |
| US-20140142298-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142298-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C-FUNCTIONALIZED DERIVATIVES THEREOF | TAC3, TACR2, TACR3 | SIGMAR1 483/4885NPFFR1 796/4885NPFFR2 977/4885 |
| US-20160222018-A1 | SYNTHESIS OF IMIDAZO[1,2-a]PYRAZIN-4-IUM SALTS FOR THE SYNTHESIS OF 1,4,7-TRIAZACYCLONONANE (TACN) AND N- AND/OR C- FUNCTIONALIZED DERIVATIVES THEREOF | TAC3, TACR2, TACR3 | SIGMAR1 528/4885NPFFR1 626/4885NPFFR2 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.