Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSD | P07339 | 11/20 | 0.53 |
| ▸ | BACE1 | P56817 | 11/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15727180 | 0.92 | CTSD (0.55) | CTSDBACE1GAANFKB1NFKB2 | |
| SCHEMBL15727316 | 0.89 | CTSD (0.53) | CTSDBACE1GAA | |
| SCHEMBL15727299 | 0.85 | CTSD (0.53) | CTSDBACE1GAA | |
| SCHEMBL15750409 | 0.84 | BACE1 (0.47) | CTSDBACE1GAANFKB1NFKB2 | |
| SCHEMBL15727314 | 0.83 | CTSD (0.55) | CTSDBACE1GAA | |
| SCHEMBL23736276 | 0.82 | GAA (0.49) | CTSDBACE1GAANFKB1NFKB2 | |
| SCHEMBL15750384 | 0.80 | CTSD (0.47) | CTSDBACE1GAA | |
| SCHEMBL23736282 | 0.80 | GAA (0.47) | CTSDBACE1GAANFKB1NFKB2 | |
| SCHEMBL23736117 | 0.78 | GAA (0.47) | CTSDBACE1GAANFKB1NFKB2 | |
| SCHEMBL17884315 | 0.78 | CTSD (0.49) | CTSDBACE1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922829-B1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS INC (US) | 2021-08-11 | — | — | EP | disclosed |
| US-9309285-B2 | Macrocyclic broad spectrum antibiotics | RQX PHARMACEUTICALS, INC. (US) | 2016-04-12 | — | — | US | disclosed |
| US-20140142029-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | RQX PHARMACEUTICALS, INC. (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142029-A1 | MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS | MRPL21, PEPD, CTSC | CTSD 271/4885BACE1 44/4885GAA 978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.