Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FCGR1A | P12314 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16877297 | 0.84 | SMN1; SMN2 (0.40) | TSHRLMNAALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL3784177 | 0.80 | GAA (0.45) | TSHRLMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL21849224 | 0.77 | GRN (0.42) | TSHRLMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL21893798 | 0.77 | LMNA (0.43) | TSHRLMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL21893413 | 0.77 | ALDH1A1 (0.40) | TSHRLMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL18136489 | 0.76 | SMN1; SMN2 (0.46) | TSHRLMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL21816280 | 0.76 | SMN1; SMN2 (0.58) | TSHRLMNAALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL31588064 | 0.74 | ADORA2A (0.67) | ALDH1A1L3MBTL1SMN1; SMN2CYP2C19KDM4E | |
| SCHEMBL10559259 | 0.74 | TDP1 (0.38) | TSHRLMNAALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL3784173 | 0.74 | L3MBTL1 (0.50) | TSHRLMNAALDH1A1MAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014078378-A1 | PYRROLIDINYL UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS AS TRKA KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2014-05-22 | — | — | WO | disclosed |