Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 15/20 | 0.56 |
| ▸ | PLK1 | P53350 | 3/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.48 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.48 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17226098 | 0.91 | REN (0.61) | RENPLK1CTSDPLK3PLK2 | |
| SCHEMBL7852891 | 0.88 | REN (0.65) | RENPLK1CTSDPLK3PLK2 | |
| SCHEMBL7849192 | 0.88 | REN (0.65) | RENPLK1CTSDPLK3PLK2 | |
| SCHEMBL7842935 | 0.88 | REN (0.65) | RENPLK1CTSDPLK3PLK2 | |
| SCHEMBL13470161 | 0.85 | REN (0.56) | RENPLK1CTSD | |
| SCHEMBL464364 | 0.85 | PLK1 (0.56) | RENPLK1CTSDPLK3PLK2 | |
| SCHEMBL464377 | 0.84 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930126 | 0.84 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930127 | 0.84 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930164 | 0.84 | PLK1 (0.70) | RENPLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140142044-A1 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | The United States of America, as represented by the Secretary, Department of Health & Human Servic (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142044-A1 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | PLK1, PLK4, PLK3 | REN 4534/4885PLK1 1/4885CTSD 1655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.