Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 12/20 | 0.65 |
| ▸ | CTSD | P07339 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 2/20 | 0.54 |
| ▸ | CAPN1 | P07384 | 4/20 | 0.51 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.51 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842935 | 1.00 | REN (0.65) | RENCTSDPLK1CAPN1PLK3 | |
| SCHEMBL7852891 | 1.00 | REN (0.65) | RENCTSDPLK1CAPN1PLK3 | |
| SCHEMBL17226098 | 0.96 | REN (0.61) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL13470161 | 0.89 | REN (0.56) | RENCTSDPLK1 | |
| SCHEMBL464364 | 0.89 | PLK1 (0.56) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL15729472 | 0.88 | REN (0.56) | RENCTSDPLK1PLK3PLK2 | |
| SCHEMBL464377 | 0.88 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930127 | 0.88 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930164 | 0.88 | PLK1 (0.70) | RENPLK1PLK3PLK2 | |
| SCHEMBL22930126 | 0.88 | PLK1 (0.70) | RENPLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010132869-A2 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2010-11-18 | — | — | WO | disclosed |