Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 8/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15729698 | 1.00 | AGTR2 (0.54) | AGTR2F2MMP2FKBP1A | |
| SCHEMBL7857131 | 0.90 | AGTR2 (0.53) | AGTR2F2MMP2FKBP1A | |
| SCHEMBL417955 | 0.89 | AGTR2 (0.54) | AGTR2F2FKBP1A | |
| SCHEMBL20920329 | 0.89 | AGTR2 (0.52) | AGTR2F2MMP2FKBP1A | |
| SCHEMBL417958 | 0.89 | AGTR2 (0.54) | AGTR2F2FKBP1A | |
| SCHEMBL13627776 | 0.85 | MMP9 (0.45) | AGTR2MMP2 | |
| SCHEMBL15729696 | 0.80 | MC4R (0.41) | AGTR2F2 | |
| SCHEMBL7343432 | 0.80 | AGTR2 (0.53) | AGTR2 | |
| SCHEMBL7343429 | 0.80 | AGTR2 (0.53) | AGTR2 | |
| SCHEMBL6944388 | 0.75 | POLB (0.49) | AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9175038-B2 | Peptide mimetic ligands of polo-like kinase 1 polo box domain and methods of use | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2015-11-03 | — | — | US | disclosed |
| US-20140142044-A1 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | The United States of America, as represented by the Secretary, Department of Health & Human Servic (US) | 2014-05-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140142044-A1 | PEPTIDE MIMETIC LIGANDS OF POLO-LIKE KINASE 1 POLO BOX DOMAIN AND METHODS OF USE | PLK1, PLK4, PLK3 | AGTR2 4722/4885F2 3754/4885MMP2 3184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.