SCHEMBL15733007

SCHEMBL15733007

CC(C)(C)[Si](C)(C)OCCNc1ccc2c(ccn2-c2cccc(OC(F)(F)F)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 8/20 0.42
PIM1 P11309 2/20 0.37
HPGDS O60760 1/20 0.35
DHFR P00374 1/20 0.34
KCNH2 Q12809 2/20 0.33
RXRA P19793 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2B Q13224 1/20 0.33
FLT1 P17948 1/20 0.33
KDR P35968 1/20 0.33
ICMT O60725 1/20 0.33
PHGDH O43175 1/20 0.33
KCNN3 Q9UGI6 1/20 0.32
FGFR4 P22455 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15521971 0.87 DGAT1 (0.39) DGAT1HPGDSKCNH2
SCHEMBL15745367 0.84 PIM1 (0.48) DGAT1PIM1HPGDSKCNH2RXRA
SCHEMBL18661369 0.81 DGAT1 (0.42) DGAT1PIM1HPGDSFLT1KDR
SCHEMBL15733091 0.80 DGAT1 (0.53) DGAT1KCNH2KDR
SCHEMBL15522136 0.79 DGAT1 (0.41) DGAT1DHFRKCNH2KDR
SCHEMBL15745364 0.78 KDM4E (0.38) DGAT1
SCHEMBL15742157 0.76 DGAT1 (0.42) DGAT1HPGDSKCNH2KDR
SCHEMBL15733050 0.75 DGAT1 (0.54) DGAT1
SCHEMBL14062292 0.74 PTK2 (0.36) DGAT1
SCHEMBL21077669 0.74 DGAT1 (0.41) DGAT1KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3492474-B1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2021-08-11 EP disclosed
EP-3492474-B1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2021-08-11 EP disclosed
US-10385066-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-08-20 US disclosed
US-10385066-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-08-20 US disclosed
EP-3492474-A1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GlaxoSmithKline LLC (US) 2019-06-05 EP disclosed
EP-3492474-A1 INTERMEDIATES USED IN THE PRODUCTION OF DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GlaxoSmithKline LLC (US) 2019-06-05 EP disclosed
US-20190135829-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2019-05-09 US disclosed
US-20190135829-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2019-05-09 US disclosed
US-10174049-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-01-08 US disclosed
US-10174049-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2019-01-08 US disclosed
US-9796729-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2017-10-24 US disclosed
US-9796729-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2017-10-24 US disclosed
US-9738658-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2017-08-22 US disclosed
US-9738658-B2 Compounds as diacylglycerol acyltransferase inhibitors GLAXOSMITHKLINE LLC (US) 2017-08-22 US disclosed
US-20170081342-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC 2017-03-23 US disclosed
US-20170081342-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC 2017-03-23 US disclosed
US-20150322082-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2015-11-12 US disclosed
EP-2922551-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS Glaxosmithkline LLC (US) 2015-09-30 EP disclosed
WO-2014081994-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-05-30 WO disclosed
US-20140148437-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS GLAXOSMITHKLINE LLC (US) 2014-05-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170081342-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, LCAT DGAT1 1/4885PIM1 3739/4885HPGDS 453/4885
US-10385066-B2 Compounds as diacylglycerol acyltransferase inhibitors DGAT1, DGAT2, LCAT DGAT1 1/4885PIM1 1681/4885HPGDS 1062/4885
US-20140148437-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, LCAT DGAT1 1/4885PIM1 3739/4885HPGDS 453/4885
US-20150322082-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, LCAT DGAT1 1/4885PIM1 3739/4885HPGDS 453/4885
US-20190135829-A1 NOVEL COMPOUNDS AS DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS DGAT1, DGAT2, DLAT DGAT1 1/4885PIM1 1484/4885HPGDS 1204/4885
US-10174049-B2 Compounds as diacylglycerol acyltransferase inhibitors DGAT1, DGAT2, LCAT DGAT1 1/4885PIM1 1681/4885HPGDS 1062/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.