Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 7/20 | 0.56 |
| ▸ | CA2 | P00918 | 7/20 | 0.56 |
| ▸ | CA12 | O43570 | 6/20 | 0.56 |
| ▸ | CA4 | P22748 | 6/20 | 0.56 |
| ▸ | CA6 | P23280 | 6/20 | 0.56 |
| ▸ | CA7 | P43166 | 6/20 | 0.56 |
| ▸ | CA9 | Q16790 | 6/20 | 0.56 |
| ▸ | CA13 | Q8N1Q1 | 6/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 6/20 | 0.56 |
| ▸ | CISD1 | Q9NZ45 | 6/20 | 0.56 |
| ▸ | CA3 | P07451 | 5/20 | 0.56 |
| ▸ | CA5A | P35218 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11600104 | 0.85 | CISD1 (0.56) | CA1CA2CA12CA4CA6 | |
| SCHEMBL11232241 | 0.85 | CISD1 (0.77) | CA1CA2CA12CA4CA6 | |
| SCHEMBL15881406 | 0.85 | CA1 (0.43) | CA1CA2CA12CA4CA6 | |
| SCHEMBL4716674 | 0.85 | CA12 (0.70) | CA1CA2CA12CA4CA6 | |
| SCHEMBL31704157 | 0.85 | CA12 (0.70) | CA1CA2CA12CA4CA6 | |
| SCHEMBL7974511 | 0.80 | CISD1 (0.50) | CA1CA2CA12CA4CA6 | |
| SCHEMBL10933704 | 0.80 | ALDH1A1 (0.46) | CA1CA2CA12CA4CA6 | |
| SCHEMBL3201757 | 0.80 | CISD1 (0.50) | CA1CA2CA12CA4CA6 | |
| SCHEMBL15881366 | 0.80 | ALDH1A1 (0.46) | CA1CA2CA12CA4CA6 | |
| SCHEMBL2266623 | 0.78 | CA1 (0.42) | CA1CA2CA12CA4CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014082889-A1 | NOVEL IMIDAZOLINES AS DUAL INHIBITORS OF MDM2 AND MDMX | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-05 | — | — | WO | disclosed |
| US-20140148443-A1 | Novel Imidazolines as dual inhibitors of MDM2 and MDMX | HOFFMANN-LA ROCHE INC. (US) | 2014-05-29 | — | — | US | disclosed |
| US-20120251954-A1 | LITHOGRAPHIC PRINTING PLATE PRECURSOR AND METHOD OF PREPARING THE SAME | FUJIFILM CORPORATION (JP) | 2012-10-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148443-A1 | Novel Imidazolines as dual inhibitors of MDM2 and MDMX | MDM2, MDM4, TP53 | CA1 2914/4885CA2 2012/4885CA12 3899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.