Sugi Predict

Sugi Predict / Compounds / SCHEMBL4716674

SCHEMBL4716674

SCHEMBL4716674

O=C(O)c1cc(S(=O)(=O)Cl)c(Cl)cc1Cl

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA12 O43570 4/20 0.70
▸ CA1 P00915 4/20 0.70
▸ CA2 P00918 4/20 0.70
▸ CA9 Q16790 4/20 0.70
▸ CA3 P07451 3/20 0.70
▸ CA4 P22748 3/20 0.70
▸ CA6 P23280 3/20 0.70
▸ CA5A P35218 3/20 0.70
▸ CA7 P43166 3/20 0.70
▸ CA13 Q8N1Q1 3/20 0.70
▸ CA14 Q9ULX7 3/20 0.70
▸ CA5B Q9Y2D0 3/20 0.70
▸ CISD1 Q9NZ45 2/20 0.70
▸ ALDH1A1 P00352 4/20 0.58
▸ MEN1 O00255 3/20 0.58
▸ KMT2A Q03164 3/20 0.58
▸ LMNA P02545 2/20 0.58
▸ ATM Q13315 1/20 0.55
▸ TSHR P16473 3/20 0.51
▸ TDP1 Q9NUW8 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31704157 1.00 CA12 (0.70) CA12CA1CA2CA9CA3
SCHEMBL15733474 0.85 CA1 (0.56) CA12CA1CA2CA9CA3
SCHEMBL29055167 0.84 CA12 (0.70) CA12CA1CA2CA9CA3
SCHEMBL397474 0.83 CA12 (0.54) CA12CA1CA2CA9CA3
SCHEMBL7974511 0.83 CISD1 (0.50) CA12CA1CA2CA9CA3
SCHEMBL3201757 0.83 CISD1 (0.50) CA12CA1CA2CA9CA3
SCHEMBL6551060 0.83 CA12 (0.59) CA12CA1CA2CA9CA3
SCHEMBL11757774 0.82 CA12 (0.49) CA12CA1CA2CA9CA3
SCHEMBL10710144 0.82 CA12 (0.68) CA12CA1CA2CA9CA3
SCHEMBL31717970 0.82 CA12 (1.00) CA12CA1CA2CA9CA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250388615-A9 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2025-12-25 — — US disclosed
US-20250066410-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2025-02-27 — — US disclosed
US-12084472-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists ARDELYX, INC. (US) 2024-09-10 — — US disclosed
US-20220306672-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX, INC. (US) 2022-09-29 — — US disclosed
EP-3390382-B1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX INC (US) 2021-12-01 — — EP disclosed
EP-3390382-B1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS ARDELYX INC (US) 2021-12-01 — — EP disclosed
CN-108699028-B Substituted 4-phenylpyridines as non-systemic TGR5 agonists 阿德利克斯公司 2021-10-22 — — CN disclosed
US-11124490-B2 Autotaxin inhibitors UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2021-09-21 — — US disclosed
US-11124490-B2 Autotaxin inhibitors UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2021-09-21 — — US disclosed
US-10968246-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists ARDELYX, INC. (US) 2021-04-06 — — US disclosed
WO-2002046148-A1 SUBSTITUTED ANTHRANILIC ACIDS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-06-13 — — WO disclosed
EP-0113151-B1 PRINTING MEDIUM AND USE THEREOF International Business Machines Corporation (US) 1988-03-09 — — EP disclosed
EP-0113151-A2 Printing medium and use thereof International Business Machines Corporation (US) 1984-07-11 — — EP disclosed
US-4443302-A Printing medium and use thereof INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 1984-04-17 — — US disclosed
US-4377521-A ANTILIPEMIC PFIZER INC. (US) 1983-03-22 — — US disclosed
EP-0068407-A1 Aminosulfonylbenzoic acid derivatives HODOGAYA CHEMICAL CO., LTD. (JP) 1983-01-05 — — EP disclosed
US-4138399-A Sulfamylbenzoic acid PFIZER INC. (US) 1979-02-06 — — US disclosed
US-4124590-A CARDIOVASCULAR DISORDERS, ANTILIPEMIC AGENTS PFIZER INC. (US) 1978-11-07 — — US disclosed
US-3992441-A ANTILIPEMIC PFIZER INC. (US) 1976-11-16 — — US disclosed
US-3953476-A DIURETICS MERCK & CO., INC. (US) 1976-04-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250066410-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, GLP1R CA12 4840/4885CA1 4826/4885CA2 4604/4885
US-11124490-B2 Autotaxin inhibitors ENPP2, ATXN10, ATXN2L CA12 4101/4885CA1 3991/4885CA2 2958/4885
US-20250388615-A9 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, FFAR3 CA12 4486/4885CA1 3827/4885CA2 3648/4885
US-10968246-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists GPR119, GIPR, GLP1R CA12 4840/4885CA1 4826/4885CA2 4604/4885
US-20220306672-A1 SUBSTITUTED 4-PHENYL PYRIDINE COMPOUNDS AS NON-SYSTEMIC TGR5 AGONISTS GPR119, GIPR, GLP1R CA12 4840/4885CA1 4826/4885CA2 4604/4885
US-12084472-B2 Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists GPR119, GIPR, GLP1R CA12 4840/4885CA1 4826/4885CA2 4604/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.