Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CISD1 | Q9NZ45 | 6/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 3/20 | 0.50 |
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | CA6 | P23280 | 3/20 | 0.50 |
| ▸ | CA7 | P43166 | 3/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.50 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.50 |
| ▸ | CA3 | P07451 | 2/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL397474 | 0.86 | CA12 (0.54) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL3527127 | 0.85 | CA12 (0.41) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL25404513 | 0.84 | CA1 (0.53) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL7564592 | 0.84 | CISD1 (0.49) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL2876194 | 0.84 | CISD1 (0.72) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL30563542 | 0.84 | CA1 (0.53) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL4716674 | 0.83 | CA12 (0.70) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL31704157 | 0.83 | CA12 (0.70) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL6551059 | 0.81 | FABP4 (0.38) | CISD1CA12CA1CA2CA4 | |
| SCHEMBL13544474 | 0.80 | APP (0.50) | CISD1CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025215115-A1 | COMPOUNDS FOR USE THE TREATMENT OF CANCER, NEURODEGENERATIVE DISEASES, PSYCHIATRIC DISORDERS, INFLAMMATION, EPILEPSY AND SEIZURES | B&A ONCOMEDICAL (FR) | 2025-10-16 | — | — | WO | disclosed |
| US-20220259167-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2022-08-18 | — | — | US | disclosed |
| WO-2020257940-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020257940-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | UNIVERSITY HEALTH NETWORK (CA) | 2020-12-30 | — | — | WO | disclosed |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20180305304-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | THE JOHNS HOPKINS UNIVERSITY | 2018-10-25 | — | — | US | disclosed |
| EP-3365325-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | Cardioxyl Pharmaceuticals Inc. (US) | 2018-08-29 | — | — | EP | disclosed |
| WO-2017070084-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2017-04-27 | — | — | WO | disclosed |
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | XIANG JASON SHAOYUN | 2010-02-04 | — | — | US | disclosed |
| US-7632838-B2 | 11-beta HSD1 inhibitors | WYETH (US) | 2009-12-15 | — | — | US | disclosed |
| CN-1372541-A | Sulfonylcarboxamide derivatives, process for their preparation and their use as medicaments | AVENTIS PHARMA GMBH (DE) | 2002-10-02 | — | — | CN | disclosed |
| WO-2002072538-A1 | IMPROVED METHOD FOR PRODUCING SULFONYL CARBOXAMIDE DERIVATIVES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-09-19 | — | — | WO | disclosed |
| EP-1218341-A1 | SULFONYL CARBOXAMIDE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2002-07-03 | — | — | EP | disclosed |
| US-20020072520-A1 | Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2002-06-13 | — | — | US | disclosed |
| US-6342512-B1 | ANTILIPEMIC AGENTS, ATHERIOSCLEROSIS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-01-29 | — | — | US | disclosed |
| WO-2001016094-A1 | SULFONYL CARBOXAMIDE DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-03-08 | — | — | WO | disclosed |
| EP-0788494-B1 | PROCESS FOR THE PREPARATION OF FUROSEMIDE | PROTEOS SRL (IT) | 2000-02-09 | — | — | EP | disclosed |
| US-5739361-A | PHOTOCHLORINATION, SULFONATION, AMMONOLYSIS AND CONDENSATION WITH FURFURYLAMINE | PROTEOS S.R.L. (IT) | 1998-04-14 | — | — | US | disclosed |
| EP-0788494-A1 | PROCESS FOR THE PREPARATION OF FUROSEMIDE | PROTEOS S.R.L. (IT) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996012714-A1 | PROCESS FOR THE PREPARATION OF FUROSEMIDE | PROTEOS S.R.L. (IT) | 1996-05-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029648-A1 | 11-Beta HSD1 Inhibitors | HSD11B1, HSD3B1, HSD11B2 | CISD1 252/4885CA12 3103/4885CA1 2701/4885 |
| US-20180305304-A1 | N-HYDROXYLSULFONAMIDE DERIVATIVES AS NITROXYL DONORS | TNNI3, TNNT2, TNNC1 | CISD1 1947/4885CA12 3219/4885CA1 2720/4885 |
| US-10730828-B2 | N-hydroxylsulfonamide derivatives as nitroxyl donors | TNNI3, TNNT2, TNNC1 | CISD1 1947/4885CA12 3219/4885CA1 2720/4885 |
| US-20220259167-A1 | FUROSEMIDE ANALOGUES AND COMPOSITIONS AND USES THEREOF FOR TREATMENT OF ALZHEIMER'S DISEASE | APP, AQP4, BACE1 | CISD1 2432/4885CA12 1014/4885CA1 90/4885 |
| US-20020072520-A1 | Sulfonylcarboxamide derivatives, process for their preparation and their use as pharmaceuticals | LIPA, CES1, SLC5A1 | CISD1 2375/4885CA12 3421/4885CA1 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.