Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573272 | 0.87 | TP53 (0.33) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL1573397 | 0.85 | TP53 (0.32) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL1573150 | 0.83 | CNR1 (0.34) | TP53LMNAKMT2ANPC1MAPT | |
| SCHEMBL698416 | 0.81 | CYP26A1 (0.34) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL1573151 | 0.81 | CYP26A1 (0.34) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL697679 | 0.81 | CYP26A1 (0.34) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL697288 | 0.81 | NPC1 (0.34) | TP53TSHRLMNAKMT2ASMN1; SMN2 | |
| SCHEMBL1573467 | 0.80 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL704577 | 0.80 | ADRA2A (0.38) | ADRA2AADRA2BADRA2CADRA1AADRA1B | |
| SCHEMBL697287 | 0.79 | NPC1 (0.35) | TSHRLMNAKMT2ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981853-B1 | SUBSTITUTED IMIDAZOLES AND THEIR USE AS PESTICIDES | PFIZER LTD (GB) | 2011-04-13 | — | — | EP | claimed |
| US-7547718-B2 | Substituted imidazoles | PFIZER LIMITED (GB) | 2009-06-16 | — | — | US | claimed |