Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PPIB | P23284 | 1/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.39 |
| ▸ | PPIG | Q13427 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.37 |
| ▸ | CCND1 | P24385 | 1/20 | 0.37 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26130465 | 0.86 | ALOX5 (0.40) | TSHRALDH1A1BCHE | |
| SCHEMBL8960248 | 0.83 | TSHR (0.41) | TSHRALDH1A1L3MBTL1IDO1CCNB2 | |
| SCHEMBL8392441 | 0.82 | KCNH2 (0.41) | CA1CA2CA9 | |
| SCHEMBL12762248 | 0.82 | CETP (0.43) | TSHRALDH1A1L3MBTL1BCHE | |
| SCHEMBL9563424 | 0.81 | TSHR (0.40) | TSHRALDH1A1L3MBTL1IDO1LMNA | |
| SCHEMBL1415749 | 0.81 | TSHR (0.40) | TSHRALDH1A1L3MBTL1IDO1LMNA | |
| SCHEMBL8592588 | 0.81 | ALDH1A1 (0.40) | TSHRALDH1A1L3MBTL1IDO1LMNA | |
| SCHEMBL9573261 | 0.80 | GAA (0.39) | TSHRALDH1A1PPIBPPIDPPIG | |
| Hydrochloric Acid SCHEMBL28524418 | 0.80 | AGXT (0.44) | TSHRALDH1A1IDO1CCNB2CDK1 | |
| SCHEMBL6949217 | 0.80 | TAAR1 (0.42) | TSHRLTB4RLTB4R2IDO1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1548005-B1 | PROCESS FOR PRODUCING 2-SUBSTITUTED PYRIDINE DERIVATIVE | KURARAY CO (JP) | 2011-04-13 | — | — | EP | disclosed |
| US-7560563-B2 | Process for producing 2-substituted pyridine derivative | KURARAY CO., LTD. (JP) | 2009-07-14 | — | — | US | disclosed |
| US-20060041142-A1 | Process for producing 2-substituted pyridine derivative | KURARAY CO., LTD. (JP) | 2006-02-23 | — | — | US | disclosed |
| EP-1548005-A1 | PROCESS FOR PRODUCING 2-SUBSTITUTED PYRIDINE DERIVATIVE | Kuraray Co., Ltd. (JP) | 2005-06-29 | — | — | EP | disclosed |
| US-5652247-A | VASOPRESSIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD (JP) | 1997-07-29 | — | — | US | disclosed |
| US-5436254-A | Vaopressin antagonists | OTSUKA PHARMACEUTICAL COMPANY, LTD. (JP) | 1995-07-25 | — | — | US | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0382185-B1 | Carbostyril derivatives | OTSUKA PHARMA CO LTD (JP) | 1994-06-15 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| US-5225402-A | Vasopressin antagonist, vasodilation, hypotensive, diuretics and anticoagulants | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1993-07-06 | — | — | US | disclosed |
| EP-0382185-A2 | Carbostyril derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1990-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060041142-A1 | Process for producing 2-substituted pyridine derivative | IDH2, IDH1, NDUFS5 | TSHR 2290/4885ALDH1A1 950/4885PPIB 2151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.