Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.58 |
| ▸ | IKBKE | Q14164 | 3/20 | 0.58 |
| ▸ | PRKACA | P17612 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3B | Q9UH17 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.37 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15737940 | 0.78 | PRKACA (0.47) | TBK1IKBKEPRKACAROCK1CSNK2A2 | |
| SCHEMBL15737873 | 0.77 | TBK1 (0.58) | TBK1IKBKEPRKACAROCK1CSNK2A2 | |
| SCHEMBL15737243 | 0.77 | ALDH1A1 (0.57) | TBK1PRKACAROCK1CSNK2A2CSNK2A1 | |
| SCHEMBL15738606 | 0.76 | TBK1 (0.60) | TBK1IKBKEPRKACAROCK1CSNK2A2 | |
| SCHEMBL15738283 | 0.74 | TBK1 (0.57) | TBK1IKBKEPRKACAROCK1CSNK2A2 | |
| SCHEMBL4525537 | 0.74 | SCN9A (0.57) | TBK1IKBKEROCK1SCN9ATMIGD3 | |
| SCHEMBL15737242 | 0.74 | IKBKE (0.59) | TBK1IKBKEPRKACAROCK1CSNK2A2 | |
| SCHEMBL14058958 | 0.74 | TBK1 (1.00) | TBK1IKBKE | |
| SCHEMBL15736317 | 0.72 | TBK1 (0.61) | TBK1IKBKEPRKACAROCK1CSNK2A2 | |
| SCHEMBL13357509 | 0.72 | PRKACA (0.70) | PRKACAROCK1GPR142 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249114-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20140148457-A1 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148457-A1 | Thiazole derivatives | TBK1, IRAK1, IRF3 | TBK1 1/4885IKBKE 17/4885PRKACA 451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.