Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 3/20 | 0.78 |
| ▸ | CCR2 | P41597 | 5/20 | 0.77 |
| ▸ | F10 | P00742 | 9/20 | 0.71 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.54 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.54 |
| ▸ | SRC | P12931 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5378162 | 0.87 | CCR2 (1.00) | PLA2G10CCR2F10GPR35NOD2 | |
| SCHEMBL28109529 | 0.86 | PLA2G10 (0.64) | PLA2G10CCR2F10 | |
| SCHEMBL3647083 | 0.86 | PLA2G10 (0.71) | PLA2G10CCR2F10F2 | |
| SCHEMBL28206476 | 0.85 | CCR2 (0.64) | PLA2G10CCR2F10NOD2NOD1 | |
| SCHEMBL25145010 | 0.85 | CCR2 (0.67) | PLA2G10CCR2F10NOD2NOD1 | |
| SCHEMBL4373632 | 0.85 | CCR2 (0.73) | PLA2G10CCR2F10GPR35NOD2 | |
| SCHEMBL5624852 | 0.84 | CCR2 (0.77) | PLA2G10CCR2F10GPR35NOD2 | |
| SCHEMBL29933820 | 0.84 | HDAC6 (0.70) | PLA2G10CCR2F10 | |
| SCHEMBL3963187 | 0.83 | PLA2G10 (0.83) | PLA2G10CCR2F10GPR35F2 | |
| SCHEMBL3722974 | 0.83 | PPARG (0.68) | PLA2G10CCR2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101151246-B | 1-benzylindole-2-carboxamide derivatives | ORGANON NV | 2011-04-13 | — | — | CN | claimed |
| US-7671080-B2 | 1-benzylindole-2-carboxamide derivatives | N.V. ORGANON (NL) | 2010-03-02 | — | — | US | claimed |
| US-20080280923-A1 | 1-Benzylindole-2-Carboxamide Derivatives | N.V. ORGANON (NL) | 2008-11-13 | — | — | US | claimed |
| EP-1940788-A1 | 1-BENZYLINDOLE-2-CARBOXAMIDE DERIVATIVES | N.V. Organon (NL) | 2008-07-09 | — | — | EP | claimed |
| CN-101151246-A | 1-benzylindole-2-carboxamide derivatives | ORGANON NV (NL) | 2008-03-26 | — | — | CN | claimed |
| WO-2006100208-A9 | 1-BENZYLINDOLE-2-CARBOXAMIDE DERIVATIVES | ORGANON NV (NL) | 2007-11-22 | — | — | WO | claimed |
| WO-2006100208-A1 | 1-BENZYLINDOLE-2-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2006-09-28 | — | — | WO | claimed |
| EP-1018878-A4 | NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN | SMITHKLINE BEECHAM CORP (US) | 2001-01-10 | — | — | EP | claimed |
| EP-1018878-A1 | NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN | SmithKline Beecham Corporation (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1998041092-A1 | NOVEL INDOLECARBOXAMIDES, PHARMACEUTICAL COMPOSITIONS AND METHODSOF INHIBITING CALPAIN | SMITHKLINE BEECHAM CORPORATION (US) | 1998-09-24 | — | — | WO | claimed |
| CN-105820104-B | A kind of indoles -2- amides compound with anti-inflammatory effect and its application in preparing anti-inflammatory drugs | 温州医科大学 | 2018-12-11 | — | — | CN | disclosed |
| EP-2176221-B1 | INDOLE INDANE AMIDE COMPOUNDS USEFUL AS CB2 AGONISTS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2011-04-13 | — | — | EP | disclosed |
| CN-101151246-B | 1-benzylindole-2-carboxamide derivatives | ORGANON NV | 2011-04-13 | — | — | CN | disclosed |
| CN-101151246-B | 1-benzylindole-2-carboxamide derivatives | ORGANON NV | 2011-04-13 | — | — | CN | disclosed |
| CN-101151246-B | 1-benzylindole-2-carboxamide derivatives | ORGANON NV | 2011-04-13 | — | — | CN | disclosed |
| WO-2006100208-A9 | 1-BENZYLINDOLE-2-CARBOXAMIDE DERIVATIVES | ORGANON NV (NL) | 2007-11-22 | — | — | WO | disclosed |
| WO-2006100208-A9 | 1-BENZYLINDOLE-2-CARBOXAMIDE DERIVATIVES | ORGANON NV (NL) | 2007-11-22 | — | — | WO | disclosed |
| WO-2006100208-A1 | 1-BENZYLINDOLE-2-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2006-09-28 | — | — | WO | disclosed |
| WO-2006100208-A1 | 1-BENZYLINDOLE-2-CARBOXAMIDE DERIVATIVES | N.V. ORGANON (NL) | 2006-09-28 | — | — | WO | disclosed |
| US-6214856-B1 | TREATING NEURODEGENERATIVE DISORDERS, E.G., ALZHEIMER'S DISEASE, STROKES, TRAUMATIC BRAIN INJURY; ANTIISCHEMIC AGENTS; MUSCULAR DYSTROPHY; ALSO CATARACTS; PLATELET AGGREGATION | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280923-A1 | 1-Benzylindole-2-Carboxamide Derivatives | CNR2, CNR1, HTR2C | PLA2G10 3933/4885CCR2 830/4885F10 3071/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.