Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.73 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.62 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | F10 | P00742 | 4/20 | 0.55 |
| ▸ | F2 | P00734 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7884326 | 0.87 | KMT2A (0.72) | CCR2NOD2NOD1SRCPLA2G10 | |
| SCHEMBL1573798 | 0.85 | PLA2G10 (0.78) | CCR2NOD2NOD1SRCPLA2G10 | |
| SCHEMBL4798323 | 0.85 | NOD2 (0.85) | CCR2NOD2NOD1SRCKMT2A | |
| SCHEMBL5378162 | 0.84 | CCR2 (1.00) | CCR2NOD2NOD1SRCPLA2G10 | |
| SCHEMBL5624852 | 0.82 | CCR2 (0.77) | CCR2NOD2NOD1SRCPLA2G10 | |
| SCHEMBL7008246 | 0.81 | CCR2 (0.81) | CCR2NOD2NOD1PLA2G10GPR35 | |
| SCHEMBL6706704 | 0.80 | NOD2 (0.82) | CCR2NOD2NOD1SRCKMT2A | |
| SCHEMBL27926662 | 0.79 | CCR2 (0.73) | CCR2NOD2NOD1SRCPLA2G10 | |
| SCHEMBL3669230 | 0.78 | CCR2 (0.56) | CCR2NOD2NOD1SRCPLA2G10 | |
| SCHEMBL7881468 | 0.77 | KMT2A (0.69) | CCR2NOD2NOD1SRCKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049520-A2 | INDOLE COMPOUNDS | Ironwood Pharmaceuticals, Inc. (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008019357-A2 | INDOLE COMPOUNDS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2008-02-14 | — | — | WO | disclosed |