Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PER2 | O15055 | 1/20 | 0.37 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573644 | 0.86 | RAB9A (0.39) | RAB9ANPC1HPGDSMN1; SMN2HTT | |
| SCHEMBL1573858 | 0.85 | MAPT (0.43) | RAB9ANPC1HPGDSMN1; SMN2HTT | |
| SCHEMBL27652986 | 0.84 | HRH3 (0.42) | HTTALDH1A1KDM4EL3MBTL1KMT2A | |
| SCHEMBL2955527 | 0.84 | GAA (0.43) | RAB9ANPC1HPGDSMN1; SMN2HTT | |
| SCHEMBL1574081 | 0.82 | ALDH1A1 (0.49) | HPGDSMN1; SMN2HTTALDH1A1L3MBTL1 | |
| SCHEMBL1573842 | 0.82 | ACHE (0.47) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL1573729 | 0.80 | HDAC1 (0.39) | ALDH1A1RBP4KMT2APER2CRY2 | |
| SCHEMBL1573961 | 0.77 | SMN1; SMN2 (0.39) | RAB9ANPC1HPGDSMN1; SMN2HTT | |
| SCHEMBL2957832 | 0.76 | RAB9A (0.40) | RAB9ANPC1HPGDSMN1; SMN2HTT | |
| SCHEMBL1574406 | 0.75 | HPGD (0.50) | RAB9ANPC1HPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |
| CN-1914180-A | Indazole derivatives as hormone sensitive lipase inhibitors | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-02-14 | — | — | CN | disclosed |