Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.36 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573999 | 0.75 | HSD11B1 (0.41) | HSD11B1 | |
| SCHEMBL4092715 | 0.73 | HSD11B1 (0.41) | HSD11B1 | |
| SCHEMBL13112950 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL12057025 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL3505999 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL12057037 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL3505996 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL13819451 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL12057023 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR | |
| SCHEMBL3505997 | 0.71 | EPHX2 (0.47) | HSD11B1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2308851-A1 | Imidazolone and imidazolidinone derivatives as 11B-HSD1 inhibitors for the treatment of diabetes | F. Hoffmann-La Roche AG (CH) | 2011-04-13 | — | — | EP | disclosed |