Sugi Predict

Sugi Predict / Compounds / SCHEMBL4092715

SCHEMBL4092715

SCHEMBL4092715

NC1(CNC2C3CC4CC2CC(O)(C4)C3)Cc2ccccc2C1

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ HSD11B1 P28845 16/20 0.41
▸ JAK2 O60674 2/20 0.34
▸ JAK1 P23458 2/20 0.34
▸ TYK2 P29597 2/20 0.34
▸ JAK3 P52333 2/20 0.34
▸ EPHX2 P34913 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1573999 0.77 HSD11B1 (0.41) HSD11B1EPHX2
SCHEMBL13112950 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL3505997 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL12057023 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL12057037 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL12057025 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL3505996 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL3505999 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL13819451 0.73 EPHX2 (0.47) HSD11B1EPHX2
SCHEMBL1574037 0.73 HSD11B1 (0.46) HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2104665-A2 IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES F. Hoffmann-Roche AG (CH) 2009-09-30 — — EP disclosed
WO-2008046758-A2 IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES F. HOFFMANN-LA ROCHE AG (CH) 2008-04-24 — — WO disclosed